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KMID : 1007520020110020172
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Food Science and Biotechnology
2002 Volume.11 No. 2 p.172 ~ p.178
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Effects of Glycoprotein from Ulmus Davidiana Nakai on Hydroxyl Radical Induced-cytotoxicity,and on Activation of Nuclear Factor-Kappa B and Activator Protein-1 in Cultured Mouse Primary Thymocytes
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Lim, Kye Taek
Son, Young Ok/Lee, Jeong Chae/Lim, Jung Chae/Chung, Yong Ji
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Abstract
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Ulmus Davidiana Nakai (UDN) glycoprotein was tested for cytotoxicity on thymocytes, modulation of nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1) activities using cultured mouse primary thymocytes. Up to 50㎍/mL of UDN glycoprotein, no cytotoxic effect against thymocytes was observed. The activity of DNA binding in NF-kappa B was decreased by the addition of UDN glycoprotein (100㎍/mL), but not in the case of AP-1 as revealed by the results of electrophoretic mobility shift assay (EMSA) and western blot. UDN glycoprotein could play a critical role on the hydroxyl radical-induced signaling in the gene expression mediating immunomodulation and inflammatory response.
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